Patented Technology

Trust in the reliable technology of original TOPROL-XL

Original TOPROL-XL® (metoprolol succinate) has been manufactured with quality and commitment for more than 20 years.

Once-daily TOPROL-XL is a beta-blocker indicated for the treatment of hypertension, alone or in combination with other antihypertensives.1

Please see Important Safety Information below


Both TOPROL-XL and its authorized generic* use a patented extended-release technology2

TOPROL-XL and its authorized generic,* metoprolol succinate (distributed by Lannett Company, Inc.), are available in extended-release tablets with oral administration, providing 24-hour hypertension treatment with 1 dose daily.1

TOPROL-XL Extended Release Tablets

*Manufactured for Lannett Company, Inc. by AstraZeneca AB, Södertälje, Sweden.

Mean steady-state plasma concentrations3

TOPROL-XL maintained consistent plasma levels vs immediate-release metoprolol and immediate-release atenolol over 24 hours.3

Mean steady-state plasma concentrations

Copyright ©1990 by The Journal of Clinical Pharmacology. Adapted by permission of SAGE Publications.

  • Metoprolol is a beta1-selective (cardioselective) adrenergic-receptor-blocking agent, and at higher concentrations it also inhibits beta2-adrenoreceptors1

Dosage and Efficacy

3035818 Last Updated 11/14

References
  1. Prescribing Information for TOPROL-XL. Aralez Pharmaceuticals, Inc, Princeton, NJ.
  2. Sandberg A, Ragnarsson G, Jonsson UE, Sjögren J. Design of a new multiple-unit controlled-release formulation of metoprolol—metoprolol CR. Eur J Clin Pharmacol. 1988;33(Suppl):S3-S7.
  3. Darmansjah I, Wong E, Setiawati A, et al. Pharmacokinetic and pharmacodynamics properties of controlled release (CR/ZOK) metoprolol in healthy Oriental subjects: A comparison with conventional formulations of metoprolol and atenolol. J Clin Pharmacol. 1990;30(2suppl):S39-S45.
  4. Papademetriou V, Hainer JW, Sugg J, Munzer D, for the ATTACH Study Group. Factorial antihypertensive study of an extended-release metoprolol and hydrochlorothiazaide combination. Am J Hypertens. 2006;10(12):1217-1225.