Dosage and Efficacy

Trust in 4 dosage strengths to suit your patient’s needs

TOPROL-XL and its authorized generic, metoprolol succinate (distributed by Par Pharmaceutical), are available in 4 dosage strengths—25 mg, 50 mg, 100 mg, and 200 mg.*

Available in identical dosing options for the authorized generic of TOPROL-XL—
25 mg, 50 mg, 100 mg, and 200 mg*


*Manufactured for Par Pharmaceutical Companies, Inc by AstraZeneca AB, Södertälje, Sweden.

Have confidence in proven efficacy across all 4 doses4

Reduction in SiDBP* and SiSBP with once-daily TOPROL-XL4

Reduction in SiDBP* and SiSBP† with once-daily TOPROL-XL

Results from a US multicenter, randomized, double-blind, placebo-controlled, parallel-group, unbalanced factorial study. In part, it evaluated the antihypertensive efficacy and the safety of once-daily dosing with extended-release metoprolol succinate monotherapy and placebo in adult patients with newly diagnosed or treated essential hypertension.4

Mean baseline SiDBP 100 mm Hg and mean baseline SiSBP 150 mm Hg


*SiDBP=sitting diastolic blood pressure.

SiSBP=sitting systolic blood pressure.

For each dose vs placebo.

  • In hypertension, initiate with 25 mg to 100 mg once daily. Increase at a weekly or longer interval to optimize clinical response. Dosages above 400 mg per day have not been studied1

Safety and Side Effects

3035818 Last Updated 11/14

Important Safety Information About TOPROL-XL

WARNING: ISCHEMIC HEART DISEASE: Following abrupt cessation of therapy with beta-blocking agents, exacerbations of angina pectoris and myocardial infarction have occurred. Warn patients against interruption or discontinuation of therapy without the physician’s advice. See WARNINGS: Metoprolol Succinate; Ischemic Heart Disease in the full PI.

  • TOPROL-XL is contraindicated in severe bradycardia, heart block of second or third degree, cardiogenic shock, decompensated cardiac failure, sick sinus syndrome (unless permanent pacemaker is in place), and in patients who are hypersensitive to any component of this product
  • Worsening cardiac failure may occur during up-titration of TOPROL-XL
  • TOPROL-XL should be used with caution in patients who have bronchospastic disease, pheochromocytoma, diabetes and hypoglycemia, hepatic impairment, thyrotoxicosis, peripheral vascular disease, those who take calcium channel blockers of the verapamil and diltiazem type, or those who are undergoing major surgery
  • Avoid initiation of high-dose TOPROL-XL in patients undergoing non-cardiac surgery
  • Patients taking beta blockers with a history of anaphylactic reaction may be unresponsive to the usual doses of epinephrine used to treat allergic reactions
  • The most common adverse reactions were tiredness, dizziness, depression, shortness of breath, bradycardia, hypotension, diarrhea, pruritus, and rash
Indication for TOPROL-XL

TOPROL-XL is indicated for the treatment of hypertension, alone or in combination with other antihypertensives; the long-term treatment of angina pectoris; and the treatment of stable, symptomatic (NYHA class II or III) heart failure of ischemic, hypertensive, or cardiomyopathic origin.

*When patients order a 3-month supply (90 pills). Taxes may apply.

Patients do not need to have insurance. Medicare and Medicaid patients are also eligible. Medicare Part D prescription orders will be processed without the use of insurance and cannot be applied to true out-of-pocket (TrOOP) costs. Prescription required.

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Click here for full Prescribing InformationAdobe Reader PDF document for TOPROL-XL, including Boxed WARNING regarding Ischemic Heart Disease.

You are encouraged to report negative side effects of prescription drugs to the FDA.

Visit or call 1-800-FDA-1088.